NANCY YUK-YU IP
Department Head and Professor; Associate Dean of Science; Director, Biotechnology Research Institute and Co-Director, Molecular Neuroscience Center
(23587289; boip@ust.hk)
|
NANCY YUK-YU IP Department Head and Professor; Associate Dean of Science; Director, Biotechnology Research Institute and Co-Director, Molecular Neuroscience Center (23587289; boip@ust.hk) |
PhD, Harvard Medical School (1983)
Postdoctoral Fellow, Harvard Medical School (1983-84)
Postdoctoral Fellow, Sloan Kettering Institute (1984-85)
Laboratory Head, Medical Genetics, Lifecodes Corporation (1987-89)
Senior Staff Scientist, Regeneron Pharmaceuticals (1989-93)
Visiting Researcher, Plymouth Marine Laboratory, UK (1989-91)Current Research Activities:
Developmental and molecular neuro-biology; neurotrophic factors and their receptors; neuronal differentiation; synapse formation and neural regeneration.
Active Projects as Principal Investigator:
Characterization of the functional roles of muscle-specific kinase during xenopus embryonic development
CERG HKUST6107/98M HK$1,072,000 Sep 1998
Emerging High Impact Area of Biochip Program
HIA HIA98/99.SC05 HK$3,775,000 Jan 1999
Identification Of The Interactive Domains In The gp130 Cytokine Family Receptors
CERG HKUST6127/99M HK$1,561,700 Dec 1999
Mapping signal transduction networks by a multidisciplinary approach
RCA CA99/00.SC01 HK$5,500,000 Apr 2000
TCM projects with Mainland institutes
CMI CMI99/00.SC02 HK$305,000 Apr 2000
Investigation of the roles of ephrins and their isoforms inaxon guidance and synapse formation at neuromuscular junctions
DAG DAG99/00.SC09 HK$62,000 Jun 2000
Functional Roles of G Protein Signalling at the Neuromuscular Junction
CERG HKUST6103/00M HK$1,062,600 Nov 2000
A new family of neurotrophic factors: the ligands for the Eph-related receptor tyrosine kinases
DAG DAG97/98.SC07 HK$100,000 Mar 1998
Exploring a novel role of truncated trkB receptors during CNS neuronal development
DAG DAG98/99.SC09 HK$70,000 Mar 1999
Biotechnology Research Institute - Traditional Chinese Medicine Center
AOE AOE97/98.SC03 HK$125,000 Apr 1998
China Program on collaboration on TCM projects with research institutes in the Chinese Mainland
CP CP98/99.SC04 HK$300,000 Apr 1999
Development of Innovative Genechip Technology
ITC AF/150/99 HK$8,600,000 Oct 1999
High-throughput drug screening center for traditional Chinese medicine
ITC AF/166/99 HK$9,665,000 Oct 1999
Development of Innovative Genechip Technology
CCFL CCFL99/00.SC01 HK$800,000 Oct 1999
Gordon research conference on molecular & cellular neurobiology
CF CF00/01.SC01 HK$100,000 May 2000
Development of quality index for Sanqi (Radix Notoginseng) from Wenshan, Yunnan
ITC UIM/9 HK$2,246,000 Jun 2000
Standardization and certification (S & C) of Chinese medicine
ITC ITS/173/00 HK$1,000,000 Jul 2000
Combinatorial libraries based on compounds of traditional Chinese medicine origin
ITC ITS/119/00 HK$9,917,000 Oct 2000Representative Recent Publications:
Fu, A.K.Y., Cheung, W.M.W., Ip, F.C.F. and Ip, N.Y. (1999) "Identification of genes induced by neuregulin in cultured myotubes", Mol. Cell Neurosci, 14, 241-253.
Fu, A.K.Y, Smith, F.D., Zhou, H, Chu, A.H., Tsim, K.W.K., Peng, H.B. and Ip, N.Y. (1999) "Xenopus Muscle Specific Kinase: Molecular cloning and prominent expression in neural tissues during early embryonic development", Eur. J. Neurosci, 11, 373-382.
Lai, K.O., Ip, F.C.F. and Ip, N.Y. (1999) "Identification and characterization of splice variants of ephrin-A3 and ephrin-A5", FEBS Lett, 458, 265-269.
Cheung, W.M.W., Chu, P.W.K., Lung, C.H., Hui, W.S., Chu, A.H. and Ip, N.Y. (2000) "Expression of retinoid receptors during the retinoic acid-induced neuronal differentiation of a human embryonal carcinoma cell line", J. Neurochem., 75: 34-40.
Tang, H., Zhang, Z. and Ip, N.Y. (1999) "Identification and characterization of differentially expressed genes in denervated muscle", Mol. Cell. Neurosci., 16: 127-140.
Ip, F.C.F., Glass, D.J., Gies, D.R., Cheung, J., Lai, K.O., Fu, A.K.Y., Yancopoulos, G.D. and Ip, N.Y. (2000) "Cloning and characterization of muscle specific kinase (MuSK) in chicken", Mol. Cell. Neurosci., 16: 661-673.
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JERRY H. WANG Professor and Co-Director, Molecular Neuroscience Center (23588701; jerwang@ust.hk) |
PhD, Iowa State University (1965)
Postdoctoral Fellow, National Research Council of Canada (1965-66)
Professor
of Biochemistry, University of Calgary (1982-94)
Current Research Activities:
Cellular signal transduction mechanisms; cell proliferation and cancer; cell calcium and second messengers; protein phoshorylations and cellular regulation.
Active Projects as Principal Investigator:
Molecular
basis for therapeutic modulation of learning and memory & The Molecular
Neuroscience Center (MNC)
AOE
AOE97/98.SC06
HK$390,520
Apr 1998
The
structure and function relationship of neuronal cdc2-like kinase
CERG
HKUST6088/98M
HK$1,000,000
Sep 1998
Understanding
gene function and molecular bases of disease using transgenic and gene targeting
technology - The role of p39nck5ai in neuronal and muscle differentiation by
gene targeting
RCA
CA98/99.SC03-1
HK$250,000
Mar 1999
Molecular
neuroscience
HIA
HIA99/00.SC01
HK$1,200,000
Mar 2000
C42-A
Novel Neuronal Cyclin-dependent Kinase 5 Activator-binding Protein
Representative Recent Publications:
Chin,
K.,
Ohki, S., Tang, D., Cheng, H., Wang,
J.H. and Zhang, M. (1999)
"Identification and Structural Characterization of a Cdk Inhibitory Peptide
Derived from Neuronal-specific Cdk5 Activator", The
Journal of Biological Chemistry, 274 (11): 7120-7127.
Ching,
Y.P., Qi, Z. and Wang, J.H. (2000) "Cloning of Three Novel Neuronal Cdk5
Activator Binding Proteins", Gene,
242, 285-294.
Wang,
X., Ching, Y., Lam, W., Qi, Z., Zhang, M. and Wang, J.H.
(in press) "Identification of a common protein association region in
neuronal cdk5 activator", J. Biol.Chem.
Egan,
C., Durda, D., Cheng, H., Wang, J.H.
and Fujita, D.J. (1999) "Activation of Src in Human Breast Tumor Cell
Lines: Elevated Levels of Phosphotyrosine Phosphatase Activity that
Preferentially Recognizes the Src Carboxy Terminal Negative Regulatory Tyrosine
530", Oncogene,
(18): 1227-1237.
Ching,
Y., Qi, Z. and Wang, J.H. (1999) "Potential Novel Protein Inhibitor of
Neuronal Cdc2-like Kinase", Miami
Nature Biotechnology Winter Symposia, The University Biochemistry and
Molecular Biol..., Miami, U.S.A, 6 - 10 February 1999, S69a.
Lam, J.K., Tsim, K.W.K. and Wang, J.H. (1998) "Differential Roles of Cyclin-dependent Kinase 5 Activator Proteins in Muscle Differentiation", The 38th Annual Meeting of the American Society for Cell Biology, The American Society for Cell Biology, San Francisco, U.S.A, 12 - 16 December 1998, B340.
|
JEFFREY TZE-FEI WONG Professor and Director, Drug Delivery Technology Center (23587288; bcjtw@ust.hk) |
PhD, University of Toronto (1963)
Research Associate, University of Oregon (1963-65)
Professor of Biochemistry, University of Toronto (1976-90)
Current Research Activities:
Coevolution of the genetic code and pathways of amino acid biosynthesis; substrate recognition by aminoacyl-tRNA synthetases; drug delivery technologies..
Active Projects as Principal Investigator:
Identity
elements of transfer RNA for tryptophan: For enzyme binding and aminoacylation
CERG
HKUST6087/98M
HK$1,284,000
Sep 1998
Co-operative
research centre for soluble receptor biology
CRC
CRC98/01.SC04
HK$3,000,000
Jun 2000
Structural
Elucidation Of 13C- And 15N- Doubly Labelled Transfer RNA For Tryptophan By
Multidimensional NMR
Representative Recent Publications:
Yan,
X.,
Xue, H., Liu, H., Wong,
M.S., Hang, J., Wong, J.T. and Zhu,
G. (2000) "NMR studies of Bacillus subtilis tRNATrp hyperexpressed in
Escherichia coli: Assignment of imino proton signals and determination of
thermal stability", Journal of
Biological Chemistry, 275 (10): 6712-6716.
Wong,
J.T.
(1991) "Origin of Genetically Encoded Protein Synthesis: A Model Based on
Selection for RNA Peptidation", Origins of Life and Evolution of the
Biosphere, 21: 165-176.
Xue,
H.,
Shen, W., Giege, R. and Wong, J.T.
(1993)
"Identity Elements of tRNATrp: Identification and Evolutionary
Conservation", J. Biol. Chem., 268: 9316-9322.
Xue,
H and
Wong, J.T.
(1994) "Preparation of Conjugated Hemoglobins", Methods in Enzymology (ed. Everse, J., Winslow, R.M. and Vandegriff, K.D.), 231:
308-322.
Tsai,
S.P. and Wong, J.T.
(1996) "Enhancement of Erythrocyte Sedimentation Rate by Polymerized
Hemoglobin", Art
Cells Blood Subs. & Immob. Biotech., 24(5): 513-523.
Winslow, R.M., Vandegriff, K.D. and Intaglietta, M. (1997) "Dextran-hemoglobin In Advances in Blood Substitutes Industrial Opportunities and Medical Challenges", Intaglietta (eds. Tsai, S.P. and Wong, T.J.), Boston: Birkhauser, Chapter 12.
|
JAMES HACKETT Associate Professor (23587292; bcjames@ust.hk) |
PhD, University College Dublin (1978)
Research Fellow, University of Adelaide (1980-84)
Senior Lecturer, University of Adelaide (1992)
Current Research Activities:
Microbial pathogenesis; vaccine development; plasmid stability mechanisms; fermentation.
Active Projects as Principal Investigator:
The characterization of putative chromosomal stabilization genes in escherichia coli
CERG
HKUST6092/98M
HK$645,000
Oct 1998
Prevention of intestinal bacterial infections by blocking or removing human intestinal cell
receptor proteins
DAG
DAG99/00.SC02
HK$45,000
Nov 1999
A
Search For Human Epithelial Cell Receptors Recognizing The Structural PilS
Protein, And The Pilus-tip PilV Proteins of
the Salmonella Typhi Type IV Pili
Representative Recent Publications:
Zhang,
X.L., Morris, C. and
Hackett. J. (1997)
"Molecular cloning, nucleotide sequence, and function of a site-specific
recombinase encoded in the major pathogenicity island of salmonella typhi, Gene,
202, 139-146.
Wong,
D.K.H., Lam, K.H.E., Chan, C.K.P., Wong, Y.C.V.,
Wong, W.R. and Hackett, J. (1998) "Extracellular expression of human epidermal
growth factor encoded by an Escherichia coli K-12 plasmid stabilized by the
ytl2-incR system of Salmonella typhimurium", J. Indus. Microbiol. and Biotech, 21, 31-36.
Sivakesava,
S., Xu, Z.N., Chen, Y.H., Hackett, J., Huang,
R.C., Lam, E., Lam, T.L. and Siu,
K.L. (1999) "Production of excreted human epidermal growth factor (hEGF)
by an efficient recombinant Escherichia coli system", Process
Biochemistry, 34, 893-900.
Huang,
R.C., Lam, E., Chen, Y.H., Hackett, J., Lam,
T.L., Liu, D., Ma, M.C. and Siu,
K.L. (1999) "Human epidermal growth factor (hEGF) excreted by
recombinant Escherichia coli K-12 has the correct N-terminus and is fully
bioactive", Process Biochemistry,
35, 1-5.
Wong,
D.K.H., Morris, C., Lam, T.L., Wong, W.R. and
Hackett, J. (1999)
"Identification of O-antigen polymerase transcription and translation start
signals and visualization of the protein in Salmonella enterica Serovar
Typhimurium", Microbiology, 145, 2443-2451.
Zhang, X.L., Tsui, I.S.M., Yip, C.M.C., Fung, A.W.Y., Wong, D.K.H., Dai, X., Yang, Y. and Hackett, J. (2000) "Salmonella typhi uses Type IVB pili to enter human intestinal epithelial cells", Infection and Immunity, 68, 3067-3073.
|
ROBERT K. M. KO Associate Professor (23587298; bcrko@ust.hk) |
PhD, University of British Columbia (1990)
Research Associate, Chinese University of Hong Kong (1990-91)
Current Research Activities:
Free radica-related mechanisms in tissue injuries; protection against such injuries by antioxidane; antioxidant properties of TCMs in relation to their anti-aging activities.
Representative Recent Publications:
Ip,
S.P., Yiu, H.Y. and Ko, K.M.
(2000) "Differential effect of schisandrin B and dimethyl diphenyl
bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon
tetrachloride intoxicated mice", Mol.Cell.Biochem,
(205): 111-114.
Yim,
T.K. and Ko, K.M. (1999) "Methylenedioxy
group and Cyclooctadiene ring as structural determinants of schisandrin in
protecting against myocardial ischemia-reperfusion injury in rats", Biochemical
Pharmacology, 57, 77-81.
Yim,
T.K. and Ko, K.M. (1999) "Schisandrin
B protects against myocardial ischemia-reperfusion injury by enhancing
myocardial glutathione antioxidant status", Molecular
and Cellular Biochemistry, 196, 151-156.
Yim,
T.K., Wu, W.K., Pak, W.F. and Ko, K.M.
(in press) "Hepatoprotective action of an oleanolic acid-enriched extract
of Ligustrum Lucidum fruits is mediated through an enhancement on hepatic
glutathione regeneration capacity in mice", Pytotherapy Res.
Yim,
T.K., Wu, W.K., Pak, W.F., Mak, D.H.F.,
Liang, S.M. and Ko, K.M. (2000)
"Myocardial protection against ischaemia-reperfusion injury by a Polygonum
multiflorum extract supplemented Dang-Gui decoction for enriching blood , a
compound formulation, ex vivo", Phytotherapy
Res,
(14): 195-199.
Yim, T.K., Wu, W.K., Mak, D.H.F. and Ko, K.M. (1999) "Myocardial protective effect of an anthraquinone-containing extract of Polygonum multiflorum Thunb. ex vivo", Planta Medica, 64, 607-611.
|
RAYMOND S. C. WONG Associate Professor; Director, Plant Growth Facility and Director, Animal Care Facility (23587271; bcrayw@ust.hk) |
PhD, South Dakota State University (1975)
Postdoctoral Fellow, University of Toronto (1975-77)
Research Associate, University of Toronto (1978-82)
Chief Biochemist, Allelix Crop Technologies (1988-90)
Current Research Activities:
Plant biotechnology; oilseed Brassica and vegetable Brassica; oilseed storage lipid biosynthesis; food biochemistry and related research.
Active Projects as Principal Investigator:
Development
of Innovative Genechip Technology
ITC
AF/150/99
HK$8,600,000
Oct 1999
Development
of quality index for Sanqi (Radix Notoginseng) from Wenshan, Yunnan
ITC
UIM/9
HK$2,246,000
Jun 2000
Representative Recent Publications:
Huang,
R.C.,
Lam, E., Lam, T.L., Hackett, J.,
Ma, M.C., Siu, K.L., Wong,
R.S.C. and Wong, W.R. (1999) "Human epidermal growth factor excreted by
recombinant Escherichia coli K-12 has the correct N-terminus and is fully
bioactive", Process Biochemistry,
35, 1-5.
Sivakesava,
S., Hackett, J., Huang, R.C., Lam, E., Lam,
T.L., Siu, K.L., Wong, R.S.C.
and Wong, W.R. (1999)
"Production of excreted human epidermal growth factor (hEGF) by an
efficient recombinant Escherichia coli system", Process Biochemistry, 34, 893-900.
Xiang,
Y., Wong, W.R, Ma, M.C. and Wong,
R.S.C. (2000) "Agrobacterium-mediated transformation of Brassica
campestris ssp. parachinensis with synthetic Bacillus thuringiensis cry1Ab and
cry1Ac genes", Plant Cell Reports,
19: 251-256.
Lam,
T.L., Wong, R.S.C and
Wong, W.R. (1997)
"Enhancement of Extracelluar Production of a Cellulomonas Fimi Exoglucanase
in Escherichia Coli by the Reduction of Promoter Strength, Enzyme and
Microbial Technology, 20: 482-488.
|
WAN-KEUNG R. WONG Associate Professor (23587299; bcwkrw@ust.hk) |
PhD, University of British Columbia (1986)
Postdoctoral Fellow, Allelix Biochemicals Inc. (1986-87)
Project Leader, Allelix Biopharmaceuticals Inc. (1988-90)
Current Research Activities:
Cloning and expression of genes in E. coli, Bacillus subtilis and Saccharamyces cerevisiae; excretion of proteins from E. coli; cellulosic waste management.
Active Projects as Principal Investigator:
Application
of recombinant cellulases to cellulose hydrolysis
DAG DAG98/99.SC04
HK$60,000
Dec 1998
Cloning,
expression and characterization of an endonuclease gene from Bacillus
Subtilis
DAG DAG00/01.SC03
HK$40,000
Jan 2001
Representative Recent Publications:
Huang,
R.C., Lam,
E., Chen, Y.H., Hackett, J., Lam,
T.L., Siu, K.L., Wong, R.S.C. and
Wong, W.R. (1999) "Human epidermal growth factor (hEGF)
excreted by recombinant Escherichia coli K-12 has the correct N-terminus and is
fully bioactive", Process
Biochemistry, 35, 1-5.
Sivakesava, S.,
Hackett, J., Huang, R.C., Lam, E., Lam,
T.L., Siu, K.L., Wong, R.S.C.
and Wong, W.R. (1999)
"Production of excreted human epidermal growth factor (hEGF) by an
efficient recombinant Escherchia coli system", Process Biochemistry, 34, 893-900.
Wong,
D.K.H., Lam,
K.H.E., Chan, C.K.P., Wong, Y.C.V.,
Wong, W.R. and Hackett, J. (1998) "Extracellular expression of human epidermal
growth factor encoded by an Escherichia coli K-12 plasmid stabilized by the
ytl2-incR system of Salmonella typhimurium", Journal of Industrial Microbiology & Biotechnology, 21, 31-36.
Xiang, Y., Wong,
W.R., Ma, M.C. and Wong, R.S.C.
(2000) "Agrobacterium-mediated transformation of Brassica camprestris ssp.
parachinensis with synthetic Bacillus thuringiensis cryIAb and cryIAc
genes", Plant Cell Reports, 19,
251-256.
Lin,
Q., Ewart, K.V., Yan, Q., Wong, W.R.,
Yang, D.S.C. and Hew, C.L. (1999) "Secretory expression and site-directed
mutagenesis studies of the winter flounder skin-type antifreeze
polypeptides", Eur. J. Biochem,
264, 49-54.
Tong, L., Lin, Q., Wong, W.R., Ali, A., Lim, D., Sung, W., Hew, C.L. and Yang, D.S.C. (2000) "Extracellular expression, purification and characterization of a winter flounder antifreeze polypeptide from Escherichia coli", Protein Expression and Purification, 18, 175-181.
|
YUNG HOU WONG Associate Professor; Associate Director, Biotechnology Research Institute (23587328; boyung@ust.hk) |
PhD,
University of Cambridge (1988)
Current Research Activities:
Receptor pharmacology; signal transduction; drug screening; neuropeptides; tumor biology.
Active Projects as Principal Investigator:
Construction
of chimeric G protein a- subunits for promiscuous receptor coupling:
Applications in drug discovery
CERG HKUST6096/98M
HK$1,286,000
Sep 1998
Construction
of Constitutively Active Mutants of The ORL1 Receptor As Tools For Discovering
Novel Analgesics
CERG HKUST6139/99M
HK$1,403,000
Oct 1999
Mapping
signal transduction networks by a multidisciplinary approach
RCA CAG99/00.SC01
HK$5,500,000
Apr 2000
Regulation
of the C-jun N-terminal Kinase by Opioid Receptors
CERG HKUST6115/00M
HK$763,200
Sep 2000
Determining
the signaling capacity of chemokine receptors which function as co-receptors for
HIV entry
DAG DAG98/99.SC14
HK$60,000
Dec 1998
Development
of Innovative Genechip Technology
ITC AF/150/99
HK$8,600,000
Oct 1999
High-throughput
drug screening center for traditional Chinese medicine
ITC AF/166/99
HK$9,665,000
Oct 1999
High-throughput
drug screening center for traditional Chinese medicine
PHY PHY99/00.SC01
US$128,497
Oct 1999
Development
of quality index for Sanqi (Radix Notoginseng) from Wenshan, Yunnan
ITC UIM/9
HK$2,246,000
Jun 2000
Combinatorial
libraries based on compounds of traditional Chinese medicine origin
Representative Recent Publications:
Mody,
S.M.,
Joshi, S.A., Ho, M.K.C. and Wong, Y.H.
(2000) "Incorporation of Gaz-Specific Sequence at the Carboxy
Terminus Increases the Promiscuity of Ga16 Towards Gi-Coupled
Receptors", Mol. Pharmacology,
57, 13-23.
Law,
P.Y., Wong, Y.H. and Loh, H.H. (2000)
"Molecular Mechanisms and Regulation of Opioid Receptor Signaling", Ann.
Rev. Pharmacol. Toxicol, 40, 389-430.
Chan,
J.S.C.,
Lee, J.W.M., Ho, M.K.C. and Wong, Y.H.
(2000) "Preactivation Permits Subsequent Stimulation of Phospholipase C by
Gi-Coupled Receptors", Mol. Pharmacol,
57, 700-708.
Antonelli,
V., Bernasconi, F., Wong, Y.H. and
Vallar, L. (2000) "Activation of B-Raf and Regulation of the Mitogen-Activated
Protein Kinase Cascade by the Goa Chain", Mol.
Biol. Cell, 11, 1129-1142.
Tso,
P.H.,
Yung, L.Y. and Wong, Y.H. (2000) "Regulation of Adenylyl Cyclase, ERK1/2 and
CREB by Gz Following Acute and Chronic Activation of the d-Opioid
Receptor", J. Neurochem, 74,
1685-1693.
Ho, M.K.C., and Wong, Y.H. (2000) "The amino terminus of Gaz is required for receptor recognition whereas its a4/ ß6 loop is essential for inhibition of adenylyl cyclase", Molecular Pharmacology, 58, 993-1000.
|
HONG XUE Associate Professor (23588707; hxue@ust.hk) |
PhD,
University of Toronto (1993)
Current Research Activities:
Structure and function of neuroreceptors; identity elements of transfer RNA.
Active Projects as Principal Investigator:
Analysis of bacillus subtilis tryptophanyl
tRNA synthetase interactions with the transfer RNA for tryptophan by NMR
CERG
HKUST6192/97M
HK$1,478,040
Jan 1998
Molecular basis for therapeutic modulation
of learning and memory & the Molecular Neuroscience Center (MNC)
AOE
AOE97/98.SC06
HK$390,520
Apr 1998
Establishment of a catalogue of genes
expressed in human liver cancer and mental diseases
ITC
AF/47/98
HK$2,000,000
Jul 1998
Establishment of Hong Kong Bioinformatics
Centre
ITC
AF/9/97
HK$794,500
Sep 1998
Understanding gene function and molecular
bases of disease using transgenic and gene targeting technology - The role of
the alpha 1 chain
of GABA receptor in neuronal function.
RCA
CA98/99.SC03-2
HK$250,000
Mar 1999
Identifying IG-like domains in invertebrates
and bacteria: a challenge for bioinformatic methods
G-HK
G-HK98/99.SC05
HK$30,000
Apr 1999
Characterization of a fragment of GABAa
receptor hyperexpressed in escherichia coli
DAG
DAG98/99.SC05
HK$70,000
Jun 1999
Archaebacterial Tryptophanyl-tRNA Synthetase:
Properties and tRNATrp Recognition
CERG
HKUST6196/99M
HK$1,414,560
Dec 1999
Fourier transform infrared spectroscopic
study of GABAa receptor structure
F-HK
F-HK99/00.SC01
HK$30,600
Jan 2000
Co-operative research centre for soluble
receptor biology
CRC
CRC98/01.SC04
HK$3,000,000
Jun 2000
A crystallization trial of GABA
receptor hyperexpressed in E Coli
CP
CP98/99.SC01-A
HK$52,500
Aug 2000
Isolation and identification of
neurologically active constituents from Traditional Chinese Medicine (TCM)
ITC
UIM/40
HK$1,636,600
Dec 2000
Human Tryptophanyl-tRNA Synthetase:
Properties And TRNA Trp Recognition
Representative Recent Publications:
Hang, J., Shi, H., Li, D., Liao,
Y., Lian, D., Xiao, Y. and Xue,
H. (2000) "Ligand binding and structural properties of segments of
GABAa receptor a1 subunit overexpressed in Escherichia coli", Journal
of Biological Chemistry, 275 (25): 18818-18823.
Hui,
K.M., Wang,
X.H. and Xue, H. (2000) "Interaction of flavones from the roots of
Scutellaria baicalensis with benzodiazepine site", Planta Medica, 66 (1): 91-93.
Rachedi, A.,
Rebhan, M. and Xue,
H. (2000) "GABA agent: a database system for retrieving integrated data
on GABA receptors", Bioinformatics,
16 (4): 301-312.
Xue, H. (1998) "Identification
of major phylogenetic branches of inhibitory ligand gated channel
receptors", J. Mol. Evol, 47,323-333.
Xue, H., Hang, J., Chu, R., Xiao,
Y., Li, H., Lee, P. and Zheng,
H. (1999) "Delineation of a membrane-proximal b-rich domain in GABAa
receptor by progressive deletions", J.
Mol. Biol, 285 (1): 55-61.
Xue, H., Zheng, H., Li, H.M., Kitmitto, A., Zhu, H.M., Lee, P. and Holzenburg, A. (2000) "A fragment of recombinant GABAA receptor a1 subunit forming rosette-like homo-oligomers", Journal of Molecular Biology, 296 (3): 739-742.
|
MINGJIE ZHANG Associate Professor (23588709; mzhang@ust.hk) |
PhD,
University of Calgary (1993)
Current Research Activities:
Multidimensional nuclear magnetic resonance; protein structure and function; neuronal signal transduction.
Active Projects as Principal Investigator:
Structural determination and functional
characterization of neuronal nitric oxide synthase inhibitor -----PIN
CERG
HKUST6084/98M
HK$932,000
Sep 1998
The structure and function relationship of
neuronal cdc2-like kinase
CERG
HKUST6088/98M
HK$1,000,000
Sep 1998
The PDZ Domain of Neuronal Nitric Oxide
Synthase: Made to be Versatile
CERG
HKUST6198/99M
HK$1,543,360
Sep 1999
Origin of the domain swapping of the DLC8
dimer observed in the NMR and X-ray structures
DAG
DAG99/00.SC06
HK$45,000
Dec 1999
Cytoplasmic Dynein Light Chains as Target
Adaptors of the Motor Complex: A Structural and Functional Study
CERG
HKUST6207/00M
HK$1,490,400
Aug 2000
Nitric oxide in excitable tissues:
physiology and disease
HFSP
HFSP99/00.SC01
US$171,429
Aug 2000
Discovery and structure-based design of
potent nNOS inhibitors from TCM using SAR by NMR
CP CP98/99.SC01-B
HK$23,000
Aug 2000
Representative Recent Publications:
Chin, C., Ohki, S., Cheng, H., Wang,
J.H. and Zhang, M. (1999)
"Identification and Structural Characterization of a Cdk Inhibitory Peptide
Derived from Neuronal Specific Cdk5 Activator", J.
Biol. Chem, 274, 7120-7127.
Fan, J., Zhang, Q., Li, M.,
Yamazaki, T., Shimizu, M. and Zhang, M.
(1998) "Protein Inhibitor of Neuronal Nitric Oxide Synthase (PIN) Binds to
a 17 Amino Acid Residues Fragment of the Enzyme", J. Biol. Chem, 273, 33472-33481.
Lo,
K.W., Zhang, Q., Li, M. and Zhang,
M. (1999) "Apoptosis-linked Gene ALG-2 Is a New member of Calpain Small
Subunit Subfamily Ca2+ -binding protein", Biochemistry,
38, 7498-7508.
Tochio, H., Hung,
F., Li, M., Bredt, D.S. and Zhang,
M. (2000) "Solution Structure and Backbone Dynamics of the Second PDZ
Domain of Postsynaptic Density-95", J.
Mol. Biol, 295, 225-237.
Tochio, H., Ohki,
S., Zhang, Q., Li, M. and Zhang,
M. (1998) "Solution Structure of a Protein Inhibitor of Neuronal Nitric
Oxide Synthase", Nature Struct. Biol,
5, 965-969.
Tochio, H., Zhang, Q., Mandal, P., Li, M. and Zhang, M. (1999) "Solution Structure of the Extended Neuronal Nitric Oxide Synthase PDZ Domain Complexed with an Associated Peptide", Nature Struct. Biol, 6, 417-421.
|
GUANG ZHU Associate Professor (23588705; gzhu@ust.hk) |
PhD,University of Maryland, College Park (1992)
Postdoctoral
Fellow, Laboratory of Chemical Physics, National Institutes of Health (1992-93)
Current Research Activities:
Application and development of multidimensional nuclear magnetic resonance techniques for structure and function study of biomacromolecules.
Active Projects as Principal Investigator:
Development
and application of multidimensional NMR signal processing and experimental
methods for a structure and function study of skp1
CERG HKUST6083/98M
HK$1,296,000
Sep 1998
Structure-function
Studies of the Cntf Receptor Complex and the Development of NMR Techniques for
Studies of the Structure and Interactions of Large Modular Proteins
CERG HKUST6199/99M
HK$1,675,520
Sep 1999
Theoretical
studies of the NMR properties of marcobiomolecules in a dilute liquid
crystalline medium
DAG
DAG99/00.SC07
HK$45,000
Dec 1999
Co-operative
research centre for soluble receptor Biology
Representative Recent Publications:
Kong, X.M.,
Sze, K.H. and Zhu, G.
(1999) "Gradient and Sensitivity Enhanced Multiple-quantum Coherence and
Its Application in Heteronuclear Multi-dimensional NMR Experiments", J.
Biomolecular NMR, 14, 133-140.
Sze, K.H.,
Kong, X. and Zhu, G.
(1999) "Measuring 3JCH by 3D J-Resolved HMBC Experiment", Tetrahedran
lett, 40, 5587-5591.
Yan, X.Z.,
Xue, H., Liu, H.Z., Hang,
J., Wong, J. and Zhu, G.
(2000) "NMR Studies of Bacillus subtilis tRNATrp Hyper-expressed in E.coli:
Assignment of Imino Proton Signals and Determination of Thermal Stability",
J. Biological Chemistry, 275,
6712-6716.
Zhu, G., Xia,
Y.L., Sze, K.H. and Yan,
X.Z. (1999) "2D and 3D TROSY Enhanced NOESY of 15N Labeled
Proteins", J. Biomlecular NMR, 14, 377-381.
Zhu, G., Kong,
X.M. and Sze, K.H. (1999)
"Gradient and Sensitivity Enhancement of Transverse Relaxation-Optimized
Spectroscopy with Water Flip-Back", J.
Biomolecular NMR, 13, 77-81.
Zhu, G., Xia, Y.L., Nicholson, L. and Sze, K.H. (2000) "TROSY-Based NMR dynamics study of proteins labeled with 15N", J. Magnetic Resonance, 143, 423-426.
|
HUEIH MIN CHEN Assistant Professor (23587294; bchmc@ust.hk) |
PhD,University of Texas, Arlington (1988)
Postdoctoral
Associate, University of Minnesota (1989-92)
Current Research Activities:
Peptide antibiotics; chemical antibiotics; constructions of anti-cancer peptides; protein folding; protein chemistry.
Active Projects as Principal Investigator:
Dynamics of the Permeabilization of Custom Antibacterial Peptides on
Lipid Bilayers
Representative Recent Publications:
Chan, S.C., Yan,
W.L., Wang,
W., Smith, D., Sheu, F.S. and Chen,
H.M. (1998) "Microscopic observations of the
different morphological changes by the anti-bacterial peptides on Klebsiella
pneunomiae and HL-60 leukaemia cells", Journal of Peptide Science, 4,
413-425.
Chen, H.M.,
Dimagno, T.J., Wang, W., Leung, E., Lee, C.H. and
Chan, S.I. (1999) "The effect of E75 of staphylococcal nuclease on enzyme
activity, protein stability and protein unfolding", European J. of Biochemistry, 261, 599-609.
Wang, W.,
Smith, D.K. and Chen, H.M. (1999)
"The effect of pH on the structure binding and model membrane lysis by
cecropin B and analogs", Biochimi.
Biophs. Acta (General subject), 1473, 418-430.
Wang,
W., Smith D., Moulding, K. and Chen, H.M. (1998) "The dependence of membrane
permeability by the anti-bacterial peptide cecropin B and its analogs CB-1, CB-3
on liposomes of different composition", Journal of Biological Chemistry,
273, 27438-27448.
Hung,
S., Wang, W., Chan, S.I. and Chen,
H.M. (1999) "Membrane lysis by the custom anti-bacterial peptides
cecropins B1 and B3: A spin-label electron spin resonance study on the
phospholipid bilayers", Biophysical
Journal, 77, 3120-3133.
Sailam, S., Arunkumar, A.I., Yu, C. and Chen, H.M. (2000) "Conformational study of a custom antibacterial peptide cecropin B1: Implication of the lytic activity", Biochim. Biophys. Acta (Protein Struc. Mol. Enzy.), 1479, 275-285.
|
KING-CHUEN CHOW Assistant Professor (23587273; bckchow@ust.hk) |
PhD, University of Toronto (1989)
Postdoctoral Fellow, Carnegie Institution of Washington (1988-92)
Current Research Activities:
Stress response of living organisms; improvement of stress tolerance of plant strains by genetic engineering; gene overexpression systems for plants; molecular evolution.
Active Projects as Principal Investigator:
Isolation and characterization of the cDNAs
that encode antifreeze proteins of winter rye
DAG
DAG97/98.SC02
HK$73,780 Feb 1998
Representative Recent Publications:
Chow,
K.C. and Tung, W.L. (1998) "Overexpression
of dnaK/dnaJ and groEL confers Freeze Tolerance to Escherichai coli",
Biochemical and Biophysical Research
Communications, 253, 502-505.
Chow,
K.C. (2000) "Hsp70 (DnaK) - an evolution facilitator?", Trends
in Genetics, 16 (11), 484-485.
Chow,
K.C. and Tung, W.L. (1999) "Electrotransformation
of Chlorella vulgaris", Plant
Cell Reports, 18, 778-780.
Chow,
K.C. and Tung, W.L. (2000)
"Magnetic field exposure stimulates transposition through the induction of
DnaK/J synthesis", Biochem Biophys
Res Comm, 270 (3): 745-748.
Chow,
K.C. and Tung, W.L. (2000)
"Magnetic field exposure enhances DNA repairing through the induction of
DnaK/J synthesis", FEBS Letters, 478,
133-136.
Chow, K.C., Wong, W.R. and Lam, K.H.E. (1998) "Construction of an efficient Bacillus subtilis system for extracellular production of heterologous proteins", J. Biotechnology, 63, 167-177.
|
YI-FAN HAN Assistant Professor (23587293; bcyfhan@ust.hk) |
PhD, Medical College of Ohio (1991)
Research Fellow, National Institutes of Health (1991-94)
Visiting Scientist, Hoechst AG (1985-86)
Current Research Activities:
Memory enhancers and analgesics, including those from Chinese medicinal herbs; protein phosphorylation and dephosphorylation in neuronal functions.
Active Projects as Principal Investigator:
Studies of Bis(7)-THA, a novel dimeric AChE inhibitor,
on cholinesterase activities and spatial memory: comparison with E2020,
Huperzine A and THA
DAG
DAG98/99.SC02
HK$60,000 Jan 1999
Studies of Bis-THAs, Novel Dimeric AChE Inhibitors, on
Cholinesterase Activities and Spatial Memory : Comparison with E2020, Huperzine
A, and THA
CERG
HKUST6236/99M
HK$709,500 Sep 1999
Collaboration with Shanghai Institute of Materia Medica,
CAS
CMI
CMI99/00.SC01
HK$150,000 Apr 2000
Combinatorial libraries based on compounds of
traditional Chinese medicine origin
ITC
ITS/119/00
HK$9,917,000 Oct 2000
Isolation and identification of neurologically active
constituents from Traditional Chinese Medicine (TCM)
ITC
UIM/40
HK$1,636,600 Dec 2000
Representative Recent Publications:
Han,
Y.F., Carlier, P.R., Chow, E.S.H., Wang, H, Lieu,
T.X. and Pang, Y.P. (1999) "Evaluation of short-tether bis-THA AChE
inhibitor. A further test of the dual binding site hypothesis", Bio-organic
& Medicinal Chem. Lett, 8, 351.
Wang,
H, Carlier, P.R., Ho, W.L., Lee,
N.T.K., Li, C.P.L., Pang, Y.P. and Han, Y.F. (1999) "Effects of
Bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE", Neuroreport,
10, 789.
Liu,
J, Ho, W.L., Lee, N.T.K., Carlier,
P.R., Pang, Y.P. and Han, Y.F.
(2000) "Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses
AF64A-induced deficits in navitational memory in rats", Neuroscience
Letters, 282, 165-168.
Wang,
H, Carlier, P.R., Ho, W.L., Lee,
N.T.K., Pang, Y.P. and Han, Y.F.
(1999) "Reversal of scopolamine-induced deficits in spatial navigation
performance in rats by bis(7)-THA:a novel dimeric AChE inhibitor", Acta Pharmacol Sinica, 20, 211.
Wu,
D.C, Xiao, X.Q, Chen, P.M.Y., Ng,
A.K.Y., Chung, W., Carliet, P.R.,
Yu, Y. and Han, Y.F. (2000) "Protection against ischemic injury in primary
cultured astrocytes of mouse cerebral cortex by bis(7)-tacrine, a novel
anti-Alzheimer's agents", Neuroscience
Letters, 288, 1-4.
Chao, Y.L., Wang, H., Xue, H., Carlier, P.R., Hui, K.M., Pang, Y.P., Li, Z.W. and Han, Y.F. (1999) "Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABAa receptor antagonist", NeuroReport, 10, 795.
|
CHUN LIANG Assistant Professor (23587296; bccliang@ust.hk) |
PhD,Brown University (1993)
Current Research Activities:
Mechanism and cell cycle control of DNA
replication in the budding yeast Saccharomyces cerevisiae; control of DNA
replication in normal and cancer cells.
Active Projects as Principal Investigator:
Mechanism and cell cycle control of DNA
replication in the budding yeast saccharomyces cerevisiae
DAG
DAG98/99.SC01
HK$100,000
Nov 1998
Mechanism and cell cycle control of DNA
replication in the budding yeast Saccharomyces cerevisiae
CERG
HKUST6193/99M
HK$1,099,840
Sep 1999
A novel molecular method for diagnosis,
early detection and mass screening of urinary bladder carcinoma
DAG
DAG99/00.SC04
HK$45,000
Nov 1999
Identificaton of proteins for initiation of
DNA replication in Saccharomyces cerevisiae using novel genetic screening
strategies
CERG
HKUST6203/00M
HK$954,000
Sep 2000
Development of anticancer drugs using the
antisense strategy
DAG
DAG00/01.SC01
HK$60,000
Dec 2000
Representative Recent Publications:
Gerbi,
S.A., Bielinsky, A., Liang, C.,
Lunyak, V. and Urnov, F. (1999) "Methods to Map Origins of Replication in
Eukaryotes", Eukaryotic DNA
Replication: A Practical Approach, Oxford University Press, Oxford, England,
1-42.
Weinreich,
M., Liang, C. and Stillman, B. (1999)
"The Cdc6p Nucleotide Binding Motif is Required for Loading Mcm Proteins
onto Chromatin", Proc. Natl. Acad.
Sci., USA, 96, 441-446.
Fu,
X. and Liang, C. (1999) "A Multicopy Suppressor Screen for Orc4
Interacting Proteins in S. cerevisiae", Eukaryotic DNA Replication, Cold Spring Harbor Laboratory, Cold
Spring Harbor, N.Y., USA, 15-19, Sep 99, 71.
Zhang,
Y. and Liang, C. (1999)
"Identification of the Budding Yeast Mcm5 Interacting Proteins by a
Multicopy Suppressor Screen", Eucaryotic
DNA Replication, Cold Spring Harbor Laboratory, Cold Spring harbor, N.Y.,
USA, 15-19 Sep 99, 226.
Liang,
C. and Stillman, B. (1997) "Persistent initiation
of DNA replication and chromatin bound MCM proteins during the cell cycle in
cdc6 mutants", Genes Dev., 11, 3375-3386.
Liang,
C.,
Weinreich, M. and Stillman, B. (1995) "ORC and Cdc6p interact
and determine the frequency of initiation of DNA replication in the genone",
Cell, 81, 667-676.
RANDY YAT CHOI POON Assistant Professor (23588703; bcrandy@ust.hk) |
PhD, Cambridge University (1994)
Postdoctoral Fellow, The Salk Institute (1994-96)
Current Research Activities:
Molecular basis of cell cycle control in normal and cancer cells.
Active Projects as Principal Investigator:
Penetration of mammalian cell membranes with peptides
DAG DAG97/98.SC03 HK$68,106 Jan 1998
Characterization of the cyclin-dependent kinase interactors skp1 and skp2 in normal and transformed cells
CERG HKUST6090/98M HK$1,072,000 Aug 1998
Novel approach for identifying human cell cycle control genes by rescue of yeast deletion mutants
DAG DAG98/99.SC03 HK$60,000 Jan 1999
Functional Characterization of Prohibitin in Cell Cycle Control and Senescence
CERG HKUST6194/99M HK$709,500 Aug 1999
Delivery of genes into mammalian cells by retrovirus systems
DAG DAG99/00.SC03 HK$45,000 Jan 2000
The effects of ectopic expression of the evolutionary diverged yeast Cak1p in human cells
DAG DAG00/01.SC02 HK$60,000 Dec 2000
Representative Recent Publications:
Arooz, T., Yam, C.H., Siu, W.Y., Lau, A., Li, K.K.W. and Poon, R.Y.C. (2000) "On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells", Biochemistry, 19: 9494-9501.
Yam, C.H., Ng, R.W.M., Siu, W.Y., Lau, A. and Poon, R.Y.C. (1999) "Regulation of Cyclin A-Cdk2 Activity by SCF Component Skp1 and F-box Protein Skp2", Molecular and Cellular Biology, 19, 635-645.
Yam, C.H., Siu, W.Y., Arooz, T., Chiu, C.H.S., Lau, A., Wang, X.Q. and Poon, R.Y.C. (1999) "MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins", Cancer Research, 59, 5075-5078.
Yam, C.H., Siu, W.Y., Lau, A. and Poon, R.Y.C. (2000) "Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2", Journal of Biological Chemistry, 275, 3158-3167.
Yam, C.H., Siu, W.Y., Kaganovich, D., Ruderman, J.V. and Poon, R.Y.C. (2001) "Cleavage of Cyclin A at R70/ R71 by the Bacterial Protease Ompt.", Proceedings of the National Academy of Sciences, USA, 98, 497-501.
Ongkeko, W.M., Wang, X.Q., Siu, W.Y., Lau, A., Yamashita, K., Harris, A.L., Cox, L.S. and Poon, R.Y.C. (1999) "MDM2 and MDMX target p53 for degradation but stabilize p73", Current Biology, 9, 829-832.
WU ZHENGUO Assistant Professor (23588704; bczgwu@ust.hk) |
PhD, University of Western Ontario (1995)
Postdoctoral Fellow, University of California, San Diego (1996-99)
Current Research Activities:
Signal transduction pathways mediated by kinases; roles and regulation of MAP kinases during normal muscle differentiation and in muscle tumors (Rhabdomyosarcoma).
Active Projects as Principal Investigator:
The role of serine/threonine kinase PRAK during muscle differentiation
DAG DAG99/00.SC05 HK$99,000 Nov 1999
Transcriptional Regulation of Myogenin during Myogenesis by P38 Map Kinase and Insulin-like Growth Factors
CERG HKUST6205/00M HK$763,200 Jul 2000
Molecular mechanisms by which the JNK signalling pathway inhibits muscle differentiation
DAG DAG00/01.SC04 HK$60,000 Dec 2000
Representative Recent Publications:
Wu, Z., Woodring, P.J., Bahakta, K.S., Tamura, K., Wen, F., Feramisco, J.R., Karin, M. and Wang, J.Y. (2000) "p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps", Mol. Cell. Biol., 20, 3951-3964.
Puri, P.L., Wu, Z., Zhang, P., Wood, L.D., Bhakta, K.S., Han, J., Feramisco, J.R. and Karin, M. (2000) "Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells", Genes Dev., 14, 574-584.
Xu, Q. and Wu, Z. (2000) "The insulin-like growth factor - phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in habdomyosarcoma-derived RD cells", J. Biol. Chem., 275, 36750-7.
